Pregnancy loss is a distressful experience. It is especially devastating when the losses are repetitive. Loss of pregnancy is physically and emotionally challenging ordeal. Until recently there was little a couple could do if they suffered from so-called unexplained recurrent pregnancy loss.
Research however provided information on the causes of the here to fore unexplained pregnancy losses resulting in the availability of treatment that enables women to carry their pregnancies to term.
What are causes of implantation failure?
An embryo may not implant because there is something wrong with the embryo itself that it cannot implant, or there is something in the uterine environment that does not allow a normal embryo to implant or a combination of these factors.
How can we determine the problems with the egg?
Problems within the egg can manifest clinically as a diminished ovarian reserve or premature ovarian failure. Diagnostic tests useful for identifying individuals at greater risk for diminished ovarian reserve or premature ovarian failure include :
Hormonal analysis for Follicle Stimulating Hormone [FSH], Estradiol and Inhibin Antiovarian antibodies [AOA].
How can we determine the problems within sperms?
Problems within the sperm not diagnosed by the standard parameters of semen analysis can be detected by:-
Sperm function tests, sperm DNA integrity assay [SDla], Y chromosome microdeletion assay.
How can we determine the anatomic problems within the uterus?
Problems With the Uterine Environment – Problems within the environment in which the embryo implants and fetus grows have been classified as anatomic, hormonal and immunologic.
Anatomic abnormalities of the uterus can be diagnosed by :-
How can we determine problems of hormonal response of uterus?
Hormonal response of the uterus can be diagnosed with the aid of ultrasound.
How can the immunologic factors causing implantation failure be diagnosed?
Antiphospholipid Antibody [APA] Panel
Thrombophilila Panel :- Included in the thrombophilia panel is the gene for Plasminogen Activator Inhibitor[PAI] which can detect the most common cause of defective fibrinolysis contributed by an increase in plasminogen activator inhibitor [PAI 1] concentrations.